Molecular mechanisms of microglial activation. B. Voltage- and purinoceptor-operated channels in microglia.

@article{Ills1996MolecularMO,
  title={Molecular mechanisms of microglial activation. B. Voltage- and purinoceptor-operated channels in microglia.},
  author={P{\'e}ter Ill{\'e}s and Wolfgang N{\"o}renberg and Peter J. Gebicke-Haerter},
  journal={Neurochemistry international},
  year={1996},
  volume={29 1},
  pages={13-24}
}
Cultured, proliferating microglial cells can be further activated by lipopolysaccharide (LPS) and, thereby, turned into a non-proliferating state. While proliferating cells exhibit only inwardly rectifying potassium channels, non-proliferating cells express, in addition, outwardly rectifying potassium channels. The characteristics of the two channel populations are markedly different. Inward potassium currents inactivate and can be abolished by extracellular Cs+ and Ba2+. Outward potassium… CONTINUE READING

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