Molecular mechanisms of memory reconsolidation

@article{Tronson2007MolecularMO,
  title={Molecular mechanisms of memory reconsolidation},
  author={Natalie C. Tronson and JaneR . Taylor},
  journal={Nature Reviews Neuroscience},
  year={2007},
  volume={8},
  pages={262-275}
}
Memory reconsolidation has been argued to be a distinct process that serves to maintain, strengthen or modify memories. Specifically, the retrieval of a previously consolidated memory has been hypothesized to induce an additional activity-dependent labile period during which the memory can be modified. Understanding the molecular mechanisms of reconsolidation could provide crucial insights into the dynamic aspects of normal mnemonic function and psychiatric disorders that are characterized by… Expand

Figures, Tables, and Topics from this paper

Is Reconsolidation a General Property of Memory?
TLDR
It is discussed how inconsistent results can be reconciled and what information is needed to uncover for the general use of reconsolidation. Expand
Pharmacological manipulation of memory reconsolidation: towards a novel treatment of pathogenic memories.
TLDR
Pharmacological intervention of reconsolidation processes may have clinical relevance, especially for the treatment of psychiatric disorders that are characterized by pathological memories, including post-traumatic stress disorder and addictive behaviour. Expand
Reconsolidation: maintaining memory relevance
TLDR
The adaptive function of memory reconsolidation is explored in more detail, with a strong emphasis on its role in updating memories to maintain their relevance. Expand
University of Birmingham Reconsolidation: maintaining memory relevance
The retrieval of a memory places it into a plastic state, as a result of which the memory can be disrupted or even enhanced by experimental treatment. This phenomenon has been conceptualised within aExpand
Mechanisms and Functions of Hippocampal Memory Reconsolidation
Abstract Memory reconsolidation is the process that serves to restabilize a memory that has been destabilized through memory retrieval. This retrieval-induced plasticity has been extensively studiedExpand
An Update on Memory Reconsolidation Updating
TLDR
Progress on reconsolidation updating studies is reviewed, highlighting their translational exploitation and addressing recent challenges to the reconsolidations field. Expand
The Neurobiological Bases of Memory Formation: From Physiological Conditions to Psychopathology
TLDR
This review will discuss some key biological mechanisms found to be critical for memory consolidation and strengthening, the role/s and mechanisms of memory reconsolidation, and how the interference with consolidation and/or reconsideration can modulate the retention and/ or storage of memories that are linked to psychopathologies. Expand
The Discovery of Memory Reconsolidation
Research on reconsolidation has demonstrated that consolidated memories may again enter states of transient instability following reactivation from which they must restabilize in order to persist,Expand
The University of Birmingham ( Live System ) Reconsolidation : maintaining memory relevance
The retrieval of a memory places it into a plastic state, as a result of which the memory can be disrupted or even enhanced by experimental treatment. This phenomenon has been conceptualised within aExpand
The Translational Potential of Memory Reconsolidation
Abstract Memories represent a means through which we bring to bear past experience on current processing in order to respond adaptively and predict the future. One process that reflects this utilityExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 117 REFERENCES
Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A
TLDR
This study demonstrates both a selective enhancement and an impairment of memory reconsolidation dependent on amygdalar PKA. Expand
Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation
TLDR
By infusing antisense oligodeoxynucleotides into the hippocampus of rats, this work shows that consolidation and reconsolidation are doubly dissociable component processes of memory. Expand
Aversive memory reactivation engages in the amygdala only some neurotransmitters involved in consolidation.
TLDR
It is shown that retrieved contextual fear memory is vulnerable to amnesic treatments and that the amygdala is critically involved, and these results help searching for appropriate therapeutic targets. Expand
Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
TLDR
The temporal dynamics of memory reconsolidation are dependent on the strength and age of the memory, such that younger and weaker memories are more easily reconsolidated than older and stronger memories. Expand
Memory--a century of consolidation.
TLDR
This review examines the progress made over the century in understanding the time-dependent processes that create the authors' lasting memories. Expand
Cellular and Systems Reconsolidation in the Hippocampus
TLDR
It is shown that intra-hippocampal infusions of the protein synthesis inhibitor anisomycin caused amnesia for a consolidated hippocampal-dependent contextual fear memory, but only if the memory was reactivated prior to infusion. Expand
Reconsolidation: the advantage of being refocused
  • Y. Dudai
  • Psychology, Medicine
  • Current Opinion in Neurobiology
  • 2006
TLDR
The phenomenon of reconsolidation, irrespective of its relevance to consolidation, provides a unique opportunity to tap into the molecular, cellular and circuit correlates of memory persistence and retrieval, of which the authors currently know only little. Expand
Removing pathogenic memories
TLDR
The neurobiological bases of pathogenic memory disruption are described to provide some insight into how psychotherapy works and demonstrate the two ways to forget are profoundly distinct in nature. Expand
Context memories and reactivation: constraints on the reconsolidation hypothesis.
TLDR
A systematic set of experiments failed to find evidence that the rat's reactivated memory for context becomes labile and requires a new protein to restabilize, and suggests that there may be important constraints determining when a reactivating memory requires reconsolidation. Expand
Dissociable stages of human memory consolidation and reconsolidation
TLDR
The unique contributions of wake and sleep in the development of different forms of consolidation are described, and it is shown that waking reactivation can turn a previously consolidated memory back into a labile state requiring subsequent reconsolidation. Expand
...
1
2
3
4
5
...