Molecular mechanisms of manganese mutagenesis.


The mechanism by which DNA polymerase discriminates between complementary and noncomplementary nucleotides for insertion into a primer terminus has been investigated. Apparent kinetic constants for the insertion of dGTP and dATP into the hook polymer d(C)194-d(G)12 with Escherichia coli DNA polymerase I (large fragment) were determined. The results suggest… (More)


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@article{ElDeiry1984MolecularMO, title={Molecular mechanisms of manganese mutagenesis.}, author={Wafik S El-Deiry and Kurtis M. Downey and Antero G. So}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1984}, volume={81 23}, pages={7378-82} }