Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease.

@article{Malhi2008MolecularMO,
  title={Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease.},
  author={Harmeet Malhi and Gregory J. Gores},
  journal={Seminars in liver disease},
  year={2008},
  volume={28 4},
  pages={
          360-9
        }
}
Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, which results in elevated serum concentration of free fatty acids (FFAs). Circulating FFAs provide the substrate for triacylglycerol formation in the liver, and may also be directly cytotoxic. Hepatocyte apoptosis is a key histologic feature of NAFLD, and correlates with progressive inflammation and fibrosis. The molecular pathways leading to hepatocyte apoptosis are not fully defined; however, recent studies… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 241 citations. REVIEW CITATIONS
Tweets
This paper has been referenced on Twitter 4 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 194 citations

241 Citations

0102030'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 241 citations based on the available data.

See our FAQ for additional information.