Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease.

  title={Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease.},
  author={H. Malhi and G. Gores},
  journal={Seminars in liver disease},
  volume={28 4},
  • H. Malhi, G. Gores
  • Published 2008
  • Medicine
  • Seminars in liver disease
  • Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, which results in elevated serum concentration of free fatty acids (FFAs). Circulating FFAs provide the substrate for triacylglycerol formation in the liver, and may also be directly cytotoxic. Hepatocyte apoptosis is a key histologic feature of NAFLD, and correlates with progressive inflammation and fibrosis. The molecular pathways leading to hepatocyte apoptosis are not fully defined; however, recent studies… CONTINUE READING
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