Molecular mechanisms of isocyanate induced oncogenic transformation in ovarian epithelial cells.

  title={Molecular mechanisms of isocyanate induced oncogenic transformation in ovarian epithelial cells.},
  author={Gorantla Venkata Raghuram and Neelam Pathak and Deepika Jain and Hariom Panwar and Hemant Pandey and Subodh Kumar Jain and Pradyumna Mishra},
  journal={Reproductive toxicology},
  volume={30 3},
Ovarian surface epithelium is under constant physiological pressure to maintain its integrity. Environmental toxic exposure can contribute to degenerative pathologies including ovarian cancer. Based on our current understanding, we aimed at listing mechanistic insights that contribute to ovarian carcinogenesis after exposure to methyl isocyanate, an ubiquitous environmental pollutant. Ovarian epithelial cells manifested a persistent DNA damage response along with increased accumulation of… CONTINUE READING


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