Molecular mechanisms of ionizing radiation-induced apoptosis.

  title={Molecular mechanisms of ionizing radiation-induced apoptosis.},
  author={Dianne J Watters},
  journal={Immunology and cell biology},
  volume={77 3},
Ionizing radiation activates not only signalling pathways in the nucleus as a result of DNA damage, but also signalling pathways initiated at the level of the plasma membrane. Proteins involved in DNA damage recognition include poly(ADP ribose) polymerase (PARP), DNA-dependent protein kinase, p53 and ataxia- telangiectasia mutated (ATM). Many of these proteins are inactivated by caspases during the execution phase of apoptosis. Signalling pathways outside the nucleus involve tyrosine kinases… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…