Molecular mechanisms of insulin resistance in type 2 diabetes mellitus.

  title={Molecular mechanisms of insulin resistance in type 2 diabetes mellitus.},
  author={Vandana Saini},
  journal={World journal of diabetes},
  volume={1 3},
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity in type 2 diabetes mellitus but the underlying mechanism is still unclear. It has been postulated that an increase in the intracellular concentration of fatty acid metabolites activates a serine kinase cascade, which leads to defects in insulin signaling downstream to the insulin receptor. In addition, the complex network of adipokines released from adipose tissue modulates the response of tissues to insulin… CONTINUE READING
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