Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine

@article{Eisenbrand2004MolecularMO,
  title={Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine},
  author={Gerhard Eisenbrand and Frankie Hippe and Sandra Jakobs and Stephan Muehlbeyer},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2004},
  volume={130},
  pages={627-635}
}
Indirubin, a 3, 2’ bisindole isomer of indigo, has originally been identified as the active principle of a traditional Chinese preparation and has been proven to exhibit antileukemic effectiveness in chronic myelocytic leukemia. Indirubin was detected to represent a novel lead structure with potent inhibitory potential towards cyclin-dependent kinases (CDKs) resulting from high affinity binding into the enzymes ATP binding site. This seminal finding triggered our research to improve the… CONTINUE READING