Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis.

@article{Guo2000MolecularMO,
  title={Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis.},
  author={F H Guo and Suzy A. A. Comhair and Shasha Zheng and Raed A Dweik and N Tony Eissa and Mary Jane Thomassen and William J. Calhoun and Serpil C. Erzurum},
  journal={Journal of immunology},
  year={2000},
  volume={164 11},
  pages={5970-80}
}
Evidence supporting increased nitric oxide (NO) in asthma is substantial, although the cellular and molecular mechanisms leading to increased NO are not known. Here, we provide a clear picture of the events regulating NO synthesis in the human asthmatic airway in vivo. We show that human airway epithelium has abundant expression of NO synthase II (NOSII) due to continuous transcriptional activation of the gene in vivo. Individuals with asthma have higher than normal NO concentrations and… CONTINUE READING
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Nitric oxide synthesis and breakdown

  • D. J. Stuehr
  • Biochim. Biophys
  • 1999
Highly Influential
9 Excerpts

Nitric oxide synthesis in the lung

  • R. D. Dweik, D. Laskowsdi, +4 authors S. C. Erzurum
  • J. Clin. Invest
  • 1998
Highly Influential
4 Excerpts

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