Molecular mechanisms of hepatitis C virus-induced hepatocellular carcinoma.

@article{Vescovo2016MolecularMO,
  title={Molecular mechanisms of hepatitis C virus-induced hepatocellular carcinoma.},
  author={Tiziana Vescovo and Giulia Refolo and Giancarlo Vitagliano and Gian Maria Fimia and Mauro Piacentini},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year={2016},
  volume={22 10},
  pages={853-861}
}
Hepatitis C virus (HCV) is a major leading cause of hepatocellular carcinoma (HCC). HCV-induced hepatocarcinogenesis is a multistep process resulting from a combination of pathway alterations that are either caused directly by viral factors or immune mediated as a consequence of a chronic state of inflammation. Host genetic variation is now emerging as an additional element that contribute to increase the risk of developing HCC. The advent of direct-acting antiviral agents foresees a rapid… CONTINUE READING
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