Molecular mechanisms of hepatic fibrogenesis.

  title={Molecular mechanisms of hepatic fibrogenesis.},
  author={Christopher J. Parsons and Motoki Takashima and Richard A. Rippe},
  journal={Journal of gastroenterology and hepatology},
  volume={22 Suppl 1},
Liver fibrosis, a wound-healing response to a variety of chronic stimuli, is characterized by excessive deposition of extracellular matrix (ECM) proteins, of which type I collagen predominates. This alters the structure of the liver leading to organ dysfunction. The activated hepatic stellate cell (HSC) is primarily responsible for excess collagen deposition during liver fibrosis. Two important aspects are involved in mediating the fibrogenic response: first the HSC becomes directly fibrogenic… CONTINUE READING
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