Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

@article{Sattler2007MolecularMO,
  title={Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death},
  author={Rita Sattler and Michael Tymianski},
  journal={Molecular Neurobiology},
  year={2007},
  volume={24},
  pages={107-129}
}
Excitotoxicity is one of the most extensively studied processes of neuronal cell death, and plays an important role in many central nervous system (CNS) diseases, including CNS ischemia, trauma, and neurodegenerative disorders. First described by Olney, excitotoxicity was later characterized as an excessive synaptic release of glutamate, which in turn activates postsynaptic glutamate receptors. While almost every glutamate receptor subtype has been implicated in mediating excitotoxic cell death… Expand
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TIME-DEPENDENCE OF DISTAL-TO-PROXIMAL HIPPOCAMPAL NEURODEGENERATION PRODUCED BY N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION
OF THESIS TIME-DEPENDENCE OF DISTAL-TO-PROXIMAL HIPPOCAMPAL NEURODEGENERATION PRODUCED BY N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION Excitotoxicity is the overexcitation of neurons due to the excessiveExpand
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