Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells.

@article{Zhang1999MolecularMO,
  title={Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells.},
  author={S. Zhang and J. Filep and T. Hohman and S. S. Tang and J. Ingelfinger and J. Chan},
  journal={Kidney international},
  year={1999},
  volume={55 2},
  pages={
          454-64
        }
}
  • S. Zhang, J. Filep, +3 authors J. Chan
  • Published 1999
  • Biology, Medicine
  • Kidney international
  • BACKGROUND Clinical studies have shown that the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor antagonists decrease proteinuria and slow the progression of nephropathy in diabetes, indicating that Ang II plays an important role in the development of nephropathy. We have previously reported that high levels of glucose stimulate the expression of rat angiotensinogen (ANG) gene in opossum kidney (OK) proximal tubular cells. We hypothesized that the stimulatory… CONTINUE READING
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