Molecular mechanisms of glucocorticoid-induced osteoporosis.

  title={Molecular mechanisms of glucocorticoid-induced osteoporosis.},
  author={D Patschan and Konstanze Loddenkemper and Frank Buttgereit},
  volume={29 6},
Bone loss resulting from long-term glucocorticoid therapy is common and clinically relevant. A number of different glucocorticoid-mediated effects are responsible for the reduction in bone density: (i) glucocorticoid-induced direct impairment of osteoblast, osteocyte, and osteoclast function leads to reduced bone remodeling and diminished repair of microdamage in bone; (ii) the effects of parathyroid hormone (PTH) might be more pronounced in the presence of glucocorticoids, whereas vitamin D… CONTINUE READING


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