Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists

  title={Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists},
  author={Cindy Stahn and M. L{\"o}wenberg and D. Hommes and F. Buttgereit},
  journal={Molecular and Cellular Endocrinology},
  • Cindy Stahn, M. Löwenberg, +1 author F. Buttgereit
  • Published 2007
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGCR); secondary non-genomic effects which are also initiated by the cGCR; membrane-bound glucocorticoid receptor (mGCR)-mediated non-genomic effects; non… CONTINUE READING
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