Molecular mechanisms of estrogen carcinogenesis.

  title={Molecular mechanisms of estrogen carcinogenesis.},
  author={James D. Yager and Joachim G. Liehr},
  journal={Annual review of pharmacology and toxicology},
In western society, the causes of several cancers--including breast, endometrium, ovary, liver, and prostate--have been linked to inappropriate and/or prolonged exposure to synthetic or endogenous steroidal hormones. In this review, we discuss the mechanisms of estrogen carcinogenesis with a focus on estrogen metabolism to 16 alpha-hydroxy estrone and 2- and 4-hydroxy catechol estrogens and the potential effects of these metabolites in vitro and in vivo on hamster liver and kidney and rat liver… CONTINUE READING
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