Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.

  title={Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.},
  author={Silja Wessler and Steffen Backert},
  journal={Trends in microbiology},
  volume={16 8},
Intact intercellular junctions and cell-matrix contacts are important structures in the formation and maintenance of epithelial-barrier functions against microbes. The human gastric pathogen Helicobacter pylori developed a remarkable network of strategies to alter these epithelial cell-cell and cell-matrix adhesions, which are implicated in inflammation, proliferation, cell migration and invasive growth. This review focuses on recent findings on H. pylori-induced host-cell signaling. We propose… CONTINUE READING
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