Molecular mechanisms of drug resistance.

  title={Molecular mechanisms of drug resistance.},
  author={Daniel Broderick Longley and Patrick Gerard Johnston},
  journal={The Journal of pathology},
  volume={205 2},
Resistance to chemotherapy limits the effectiveness of anti-cancer drug treatment. Tumours may be intrinsically drug-resistant or develop resistance to chemotherapy during treatment. Acquired resistance is a particular problem, as tumours not only become resistant to the drugs originally used to treat them, but may also become cross-resistant to other drugs with different mechanisms of action. Resistance to chemotherapy is believed to cause treatment failure in over 90% of patients with… CONTINUE READING
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