Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives

@article{Veenvliet2014MolecularMO,
  title={Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives},
  author={Jesse V Veenvliet and Marten P Smidt},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={71},
  pages={4703-4727}
}
Dopaminergic (DA) neurons in the ventral mesodiencephalon control locomotion and emotion and are affected in psychiatric and neurodegenerative diseases, such as Parkinson’s disease (PD). A clinical hallmark of PD is the specific degeneration of DA neurons located within the substantia nigra (SNc), whereas neurons in the ventral tegmental area remain unaffected. Recent advances have highlighted that the selective vulnerability of the SNc may originate in subset-specific molecular programming… CONTINUE READING
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