Molecular mechanisms of disease-causing missense mutations.


Genetic variations resulting in a change of amino acid sequence can have a dramatic effect on stability, hydrogen bond network, conformational dynamics, activity and many other physiologically important properties of proteins. The substitutions of only one residue in a protein sequence, so-called missense mutations, can be related to many pathological… (More)
DOI: 10.1016/j.jmb.2013.07.014


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@article{Stefl2013MolecularMO, title={Molecular mechanisms of disease-causing missense mutations.}, author={Shannon K. Stefl and Hafumi Nishi and Marharyta Petukh and Anna R. Panchenko and Emil Alexov}, journal={Journal of molecular biology}, year={2013}, volume={425 21}, pages={3919-36} }