Molecular mechanisms of dietary restriction promoting health and longevity

@article{Green2021MolecularMO,
  title={Molecular mechanisms of dietary restriction promoting health and longevity},
  author={Cara L. Green and Dudley Lamming and Luigi Fontana},
  journal={Nature Reviews Molecular Cell Biology},
  year={2021},
  volume={23},
  pages={56-73}
}
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and extending healthspan and lifespan in diverse species, including rodents and non-human primates. In this Review, we discuss the effects of dietary restriction in these mammalian model organisms and discuss accumulating data that suggest that dietary restriction results in many of the same physiological, metabolic and molecular changes responsible for the prevention of multiple ageing-associated diseases in… 
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