Molecular mechanisms of diabetic renal hypertrophy.

  title={Molecular mechanisms of diabetic renal hypertrophy.},
  author={Gunter B Wolf and Fuad N. Ziyadeh},
  journal={Kidney international},
  volume={56 2},
Altered growth of renal cells is one of the early abnormalities detected after the onset of diabetes. Cell culture studies whereby renal cells are exposed to high glucose concentrations have provided a considerable amount of insight into mechanisms of growth. In the glomerular compartment, there is a very early and self-limited proliferation of mesangial cells with subsequent hypertrophy, whereas proximal tubular cells primarily undergo hypertrophy. There is overwhelming evidence from in vivo… CONTINUE READING


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