Molecular mechanisms of developmental timing in C. elegans and Drosophila.

@article{Thummel2001MolecularMO,
  title={Molecular mechanisms of developmental timing in C. elegans and Drosophila.},
  author={Carl S Thummel},
  journal={Developmental cell},
  year={2001},
  volume={1 4},
  pages={453-65}
}
Characterization of the heterochronic genes has provided a strong foundation for understanding the molecular mechanisms of developmental timing in C. elegans. In apparent contrast, studies of developmental timing in Drosophila have demonstrated a central role for gene cascades triggered by the steroid hormone ecdysone. In this review, I survey the molecular mechanisms of developmental timing in C. elegans and Drosophila and outline how common regulatory pathways are beginning to emerge. 
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