Molecular mechanisms of dendritic spine development and remodeling

@article{Ethell2005MolecularMO,
  title={Molecular mechanisms of dendritic spine development and remodeling},
  author={Iryna M. Ethell and Elena B. Pasquale},
  journal={Progress in Neurobiology},
  year={2005},
  volume={75},
  pages={161-205}
}
Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines
TLDR
This study provides new insight into the dynamics of the neuronal cytoskeleton in mature CNS neurons and suggests that microtubules play an important, direct role in spine morphology and function.
Role of actin cytoskeleton in dendritic spine morphogenesis
Developmental plasticity of the dendritic compartment: focus on the cytoskeleton.
TLDR
This chapter focuses on the structural plasticity of dendritic arbors and spines during development and the principles and molecular mechanisms underlying this process, focusing mostly on the regulation of the cytoskeleton during dendrito- and spinogenesis.
Dendritic Spine Plasticity: Function and Mechanisms
Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888 by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of electron microscopy
Dendritic Spines: Similarities with Protrusions and Adhesions in Migrating Cells.
TLDR
Using parallels between migrating fibroblasts and dendritic spines, this work points to potential mechanisms and approaches for understanding spine development and dynamics.
Structural Modulation of Dendritic Spines during Synaptic Plasticity
TLDR
A review of recent studies has elucidated numerous molecular regulators that directly alter actin dynamics within dendritic spines and highlight likely roles of these actin-binding proteins.
Barriers in the brain: resolving dendritic spine morphology and compartmentalization
TLDR
Recent advances in tool development – both experimental and theoretical – that facilitate studying the role of the spine neck in compartmentalization of biochemical signals, membrane receptors and electrical signals in spines are reviewed.
Structural plasticity of dendritic spines
TLDR
Structural dynamics of dendritic spines is thought to play important roles in synapse plasticity and information processing, and abnormal spine structures are often associated with malfunction of the nervous system.
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