Molecular mechanisms of corticosteroid actions.

@article{Adcock2000MolecularMO,
  title={Molecular mechanisms of corticosteroid actions.},
  author={Ian M. Adcock and Kazuhiro Ito},
  journal={Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace},
  year={2000},
  volume={55 3},
  pages={
          256-66
        }
}
Corticosteroids are the most effective therapy for the treatment of inflammatory diseases such as asthma. Functionally, they act partly by inducing anti-inflammatory genes such as secretary leukocyte proteinase inhibitor, Lipocortin-1 and interleukin-1 receptor antagonist, but mainly by repression of inflammatory genes, such as cytokines, adhesion molecules, inflammatory enzymes and receptors. They act by binding to a cytosolic glucocorticoid receptor (GR), which upon binding is activated and… CONTINUE READING

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