Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping

@article{Zhao2020MolecularMO,
  title={Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping},
  author={Q. Zhao and Michael Dacre and T. Nguyen and M. Pjanic and B. Liu and Dharini Iyer and P. Cheng and Robert C Wirka and J. Kim and H. Fraser and T. Quertermous},
  journal={Genome Biology},
  year={2020},
  volume={21}
}
  • Q. Zhao, Michael Dacre, +8 authors T. Quertermous
  • Published 2020
  • Biology, Medicine
  • Genome Biology
    • Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis -regulation in primary human coronary artery vascular smooth muscle cells (HCASMCs). Results We use a pooling approach with HCASMC lines to map regulatory variants that mediate binding of the CAD-associated transcription… CONTINUE READING
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    References

    SHOWING 1-10 OF 64 REFERENCES
    Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci
    • 36
    • PDF
    TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression
    • 17
    • PDF
    Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
    • 68
    • PDF
    Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk
    • 65
    Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions
    • 244
    Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci.
    • 25
    Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
    • 221
    • PDF
    DNaseI sensitivity QTLs are a major determinant of human expression variation
    • 571
    • PDF
    Association of a transcription factor 21 gene polymorphism with hypertension.
    • 25
    • PDF
    Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk
    • 18
    • PDF