Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping

@article{Zhao2020MolecularMO,
  title={Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping},
  author={Q. Zhao and Michael Dacre and T. Nguyen and M. Pjanic and B. Liu and Dharini Iyer and P. Cheng and Robert C Wirka and J. Kim and H. Fraser and T. Quertermous},
  journal={Genome Biology},
  year={2020},
  volume={21}
}
  • Q. Zhao, Michael Dacre, +8 authors T. Quertermous
  • Published 2020
  • Biology, Medicine
  • Genome Biology
  • Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis -regulation in primary human coronary artery vascular smooth muscle cells (HCASMCs). Results We use a pooling approach with HCASMC lines to map regulatory variants that mediate binding of the CAD-associated transcription… CONTINUE READING
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