Molecular mechanisms of copper metabolism and the role of the Menkes disease protein

@article{Harrison1999MolecularMO,
  title={Molecular mechanisms of copper metabolism and the role of the Menkes disease protein},
  author={M. Harrison and Charles T. Dameron},
  journal={Journal of Biochemical and Molecular Toxicology},
  year={1999},
  volume={13}
}
Menkes disease is an X‐linked, recessive disorder of copper metabolism that occurs in approximately 1 in 200,000 live births. The condition is characterized by skeletal abnormalities, severe mental retardation, neurologic degeneration, and patient mortality in early childhood. The symptoms of Menkes disease result from a deficiency of serum copper and copper‐dependent enzymes. A candidate gene for the disease has been isolated and designated MNK. The MNK gene codes for a P‐type cation… Expand
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