Molecular mechanisms of copper homeostasis.

  title={Molecular mechanisms of copper homeostasis.},
  author={Vasiliki S Lalioti and Gemma Muru{\'a}is and Yo Tsuchiya and Diego Pulido and Ignacio V Sandoval},
  journal={Frontiers in bioscience},
The transition metal copper (Cu) is an essential trace element for all biota. Its redox properties bestow Cu with capabilities that are simultaneously essential and potentially damaging to the cell. Free Cu is virtually absent in the cell. The descriptions of the structural and functional organization of the metallothioneins, Cu-chaperones and P-type ATPases as well as of the mechanisms that regulate their distribution and functioning in the cell have enormously advanced our understanding of… CONTINUE READING


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