Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype.

@article{Orr2009MolecularMO,
  title={Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype.},
  author={A Wayne Orr and Monica Y. Lee and Julia A Lemmon and Arif Yurdagul and M Fabricio G{\'o}mez and Pamela D. Schoppee Bortz and Brian R. Wamhoff},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 2},
  pages={
          225-31
        }
}
OBJECTIVE Smooth muscle cell (SMC) phenotypic modulation, an important component of atherosclerosis progression, is critically regulated by the matrix, with normal components of the healthy SMC matrix limiting modulation and atherosclerosis-associated transitional matrix proteins promoting phenotypic modulation. We sought to determine how collagen IV (which comprises the healthy artery wall) and monomeric collagen I (which comprises atherosclerotic lesions) differentially affect SMC phenotype… CONTINUE READING

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