Molecular mechanisms of central leptin resistance in obesity.

  title={Molecular mechanisms of central leptin resistance in obesity.},
  author={Chang Hee Jung and Min-Seon Kim},
  journal={Archives of pharmacal research},
  volume={36 2},
The rapidly increasing prevalence of obesity confers a huge health burden globally. The hypothalamus plays a central role in the regulation of energy homeostasis by integrating multiple metabolic signals from peripheral organs and modulating feeding behavior and energy metabolism. Leptin, a key appetite-regulating hormone derived from the white adipose… CONTINUE READING