Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis.

@article{Batlle2012MolecularMO,
  title={Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis.},
  author={Eduard Batlle and David G Wilkinson},
  journal={Cold Spring Harbor perspectives in biology},
  year={2012},
  volume={4 1},
  pages={a008227}
}
The establishment and maintenance of precisely organized tissues requires the formation of sharp borders between distinct cell populations. The maintenance of segregated cell populations is also required for tissue homeostasis in the adult, and deficiencies in segregation underlie the metastatic spreading of tumor cells. Three classes of mechanisms that underlie cell segregation and border formation have been uncovered. The first involves differences in cadherin-mediated cell-cell adhesion that… CONTINUE READING

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