Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  title={Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018},
  author={Lorenzo Galluzzi and Ilio Vitale and Stuart A Aaronson and John Abrams and Dieter Adam and Patrizia Agostinis and Emad S Alnemri and Lucia Altucci and Ivano Amelio and David William Andrews and Margherita Annicchiarico-Petruzzelli and Alexey V. Antonov and Eli Arama and Eric H. Baehrecke and Nickolai A. Barlev and Nicolas G. Bazan and Francesca Bernassola and Mathieu J. M. Bertrand and Katiuscia Bianchi and Mikhail V. Blagosklonny and Klas Blomgren and Christoph Borner and Patricia Boya and Catherine Brenner and Michelangelo Campanella and Eleonora Candi and Didac Carmona-Gutierrez and Francesco Cecconi and Francis K.M. Chan and Navdeep S. Chandel and Emily H. Cheng and Jerry Edward Chipuk and John A. Cidlowski and Aaron Ciechanover and Gerald M. Cohen and Marcus Conrad and Juan R. Cubillos-Ruiz and Peter E. Czabotar and Vincenzo D’Angiolella and Ted M. Dawson and Valina L. Dawson and Vincenzo de Laurenzi and Ruggero De Maria and Klaus-Michael Debatin and Ralph J. Deberardinis and Mohanish Deshmukh and Nicola Di Daniele and Francesco Di Virgilio and Vishva M. Dixit and S. Jeffrey Dixon and Colin S. Duckett and Brian D. Dynlacht and Wafik S. El-Deiry and John W. Elrod and Gian Maria Fimia and Simone Fulda and Ana J. Garc{\'i}a-S{\'a}ez and Abhishek D Garg and Carmen Garrido and Evripidis Gavathiotis and Pierre Golstein and Eyal Gottlieb and Douglas R. Green and Lloyd A. Greene and Hinrich Gronemeyer and Atan Gross and Gy{\"o}rgy Hajn{\'o}czky and J. Marie Hardwick and Isaac S. Harris and Michael O. Hengartner and Claudio Hetz and Hidenori Ichijo and Marja J{\"a}{\"a}ttel{\"a} and Bertrand Joseph and Philipp J. Jost and Philippe P. Juin and William J. Kaiser and Michael Karin and Thomas Kaufmann and Oliver Kepp and Adi Kimchi and Richard N. Kitsis and Daniel J. Klionsky and Richard A Knight and Sharad Kumar and Sam W. Lee and John J. Lemasters and Beth Levine and Andreas Linkermann and Stuart A. Lipton and Richard A Lockshin and Carlos L{\'o}pez-Ot{\'i}n and Scott W. Lowe and Tom Luedde and Enrico Lugli and Marion MacFarlane and Frank Madeo and Michal Malewicz and Walter Malorni and Gwenola Manic and Jean-Christophe Marine and Seamus J. Martin and Jean-Claude Martinou and Jan Paul Medema and Patrick Mehlen and Pascal Meier and Sonia Melino and Edward A. Miao and Jeffery D. Molkentin and Ute M. Moll and Cristina Mu{\~n}oz-Pinedo and Shigekazu Nagata and Gabriel N{\'u}{\~n}ez and Andrew Oberst and Moshe Oren and Michael Overholtzer and Michele Pagano and Theocharis Panaretakis and Manolis Pasparakis and Josef M. Penninger and David M. Pereira and Shazib Pervaiz and Marcus E. Peter and Mauro Piacentini and Paolo Pinton and Jochen H. M. Prehn and Hamsa Puthalakath and Gabriel A. Rabinovich and Markus Rehm and Rosario Rizzuto and Cec{\'i}lia M. P. Rodrigues and David C. Rubinsztein and Thomas Rudel and Kevin M. Ryan and Emre Sayan and Luca Scorrano and Feng Shao and Yufang Shi and John Silke and Hans-Uwe Simon and Antonella Sistigu and Brent R. Stockwell and Andreas Strasser and Gyorgy Szabadkai and Stephen W. G. Tait and Daolin Tang and Nektarios Tavernarakis and Andrew Thorburn and Yoshihide Tsujimoto and Boris Turk and Tom Vanden Berghe and Peter Vandenabeele and Matthew G. Vander Heiden and Andreas Villunger and Herbert W. Virgin and Karen H. Vousden and Domagoj Vu{\vc}i{\'c} and Erwin F. Wagner and Henning Walczak and David Wallach and Ying Wang and James A. Wells and Will Wood and Junying Yuan and Zahra Zakeri and Boris Zhivotovsky and Laurence Zitvogel and Gerry Melino and Guido Kroemer},
  journal={Cell Death and Differentiation},
  pages={486 - 541}
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As… 
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