Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

@article{Galluzzi2017MolecularMO,
  title={Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018},
  author={Lorenzo Galluzzi and Ilio Vitale and Stuart A Aaronson and John Abrams and Dieter Adam and Patrizia Agostinis and Emad S Alnemri and Lucia Altucci and Ivano Amelio and David William Andrews and Margherita Annicchiarico-Petruzzelli and Alexey V. Antonov and Eli Arama and Eric H. Baehrecke and Nickolai A. Barlev and Nicolas G. Bazan and Francesca Bernassola and Mathieu J. M. Bertrand and Katiuscia Bianchi and Mikhail V. Blagosklonny and Klas Blomgren and Christoph Borner and Patricia Boya and Catherine Brenner and Michelangelo Campanella and Eleonora Candi and Didac Carmona-Gutierrez and Francesco Cecconi and Francis K.M. Chan and Navdeep S. Chandel and Emily H. Cheng and Jerry Edward Chipuk and John A. Cidlowski and Aaron Ciechanover and Gerald M. Cohen and Marcus Conrad and Juan R. Cubillos-Ruiz and Peter E. Czabotar and Vincenzo D’Angiolella and Ted M. Dawson and Valina L. Dawson and Vincenzo de Laurenzi and Ruggero De Maria and Klaus-Michael Debatin and Ralph J. Deberardinis and Mohanish Deshmukh and Nicola Di Daniele and Francesco Di Virgilio and Vishva M. Dixit and S. Jeffrey Dixon and Colin S. Duckett and Brian D. Dynlacht and Wafik S. El-Deiry and John W. Elrod and Gian Maria Fimia and Simone Fulda and Ana J. Garc{\'i}a-S{\'a}ez and Abhishek D Garg and Carmen Garrido and Evripidis Gavathiotis and Pierre Golstein and Eyal Gottlieb and Douglas R. Green and Lloyd A. Greene and Hinrich Gronemeyer and Atan Gross and Gy{\"o}rgy Hajn{\'o}czky and J. Marie Hardwick and Isaac S. Harris and Michael O. Hengartner and Claudio Hetz and Hidenori Ichijo and Marja J{\"a}{\"a}ttel{\"a} and Bertrand Joseph and Philipp J. Jost and Philippe P. Juin and William J. Kaiser and Michael Karin and Thomas Kaufmann and Oliver Kepp and Adi Kimchi and Richard N. Kitsis and Daniel J. Klionsky and Richard A Knight and Sharad Kumar and Sam W. Lee and John J. Lemasters and Beth Levine and Andreas Linkermann and Stuart A. Lipton and Richard A Lockshin and Carlos L{\'o}pez-Ot{\'i}n and Scott W. Lowe and Tom Luedde and Enrico Lugli and Marion MacFarlane and Frank Madeo and Michal Malewicz and Walter Malorni and Gwenola Manic and Jean-Christophe Marine and Seamus J. Martin and Jean-Claude Martinou and Jan Paul Medema and Patrick Mehlen and Pascal Meier and Sonia Melino and Edward A. Miao and Jeffery D. Molkentin and Ute M. Moll and Cristina Mu{\~n}oz-Pinedo and Shigekazu Nagata and Gabriel N{\'u}{\~n}ez and Andrew Oberst and Moshe Oren and Michael Overholtzer and Michele Pagano and Theocharis Panaretakis and Manolis Pasparakis and Josef M. Penninger and David M. Pereira and Shazib Pervaiz and Marcus E. Peter and Mauro Piacentini and Paolo Pinton and Jochen H. M. Prehn and Hamsa Puthalakath and Gabriel A. Rabinovich and Markus Rehm and Rosario Rizzuto and Cec{\'i}lia M. P. Rodrigues and David C. Rubinsztein and Thomas Rudel and Kevin M. Ryan and Emre Sayan and Luca Scorrano and Feng Shao and Yufang Shi and John Silke and Hans-Uwe Simon and Antonella Sistigu and Brent R. Stockwell and Andreas Strasser and Gyorgy Szabadkai and Stephen W. G. Tait and Daolin Tang and Nektarios Tavernarakis and Andrew Thorburn and Yoshihide Tsujimoto and Boris Turk and Tom Vanden Berghe and Peter Vandenabeele and Matthew G. Vander Heiden and Andreas Villunger and Herbert W. Virgin and Karen H. Vousden and Domagoj Vu{\vc}i{\'c} and Erwin F. Wagner and Henning Walczak and David Wallach and Ying Wang and James A. Wells and Will Wood and Junying Yuan and Zahra Zakeri and Boris Zhivotovsky and Laurence Zitvogel and Gerry Melino and Guido Kroemer},
  journal={Cell Death and Differentiation},
  year={2017},
  volume={25},
  pages={486 - 541}
}
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As… 
View on Springer
nature.com
2,460 Citations
Highly Influential Citations
78
Background Citations
526
Methods Citations
29
Results Citations
7

2,460 Citations

Mechanisms of Regulated Cell Death: Current Perspectives
TLDR
In this review, the current understanding of the molecular machinery of each type of non-apoptotic RCD mechanisms is outlined and the limitations of the terms apoptosis and necrosis to indicate microscopic findings are reported.
Cell Death and Liver Disease
TLDR
This review briefly covers the recently revised classifications of cell death and discusses their relevance to liver diseases of different etiologies.
Special Focus on Regulated Cell Death: Emerging Mechanisms and Current Perspectives in Biology and Pathology
TLDR
A broad overview on the current paradigms of nonaccidental cell death is covered, covering the major aspects of some widely recognized and more recently characterized mechanisms of cell death, highlighting the recent advancements in the understanding and classification of these manifestations, and summarizing their investigation using relevant animal models.
On the Road to Discovering the Elusive Executioner of Pyroptosis
TLDR
A critical step of pyroptosis was described and it was demonstrated that the caspase-1–dependent membrane pores led to the eventual cell swelling and lysis following infection, contributing to the understanding of how pyroPTosis is regulated in a stepwise manner.
Guidelines and recommendations on yeast cell death nomenclature
TLDR
Unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria are proposed.
Multiple cell death modalities and their key features (Review)
TLDR
The hallmarks of different cell death modes are systematically described and are fitted into a simple classification system, where the cell death entities are primarily categorized into programmed cell death (PCD) or non-PCD based on their signal dependency.
The modulation of necroptosis and its therapeutic potentials
TLDR
A new emerging concept in cell death biology is introduced and a first entry into the research field of necroptosis is provided to provide an unprecedented opportunity to pathological necrosis-driven human diseases.
Autophagy-dependent cell death – where, how and why a cell eats itself to death
TLDR
A review of recent findings that demonstrate autophagy-dependent cell death in various contexts and begin to elucidate molecular mechanisms that render autophagosomes a lethal process.
The molecular machinery of regulated cell death
TLDR
The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.
Cell death pathways: intricate connections and disease implications
TLDR
Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s); it is increasingly clear that none of these pathways operate alone.
...
...

References

SHOWING 1-10 OF 1,109 REFERENCES
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
TLDR
A functional classification of cell death subroutines is proposed that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic programmed cell death, regulated necrosis, autophagic cell death and mitotic catastrophe.
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
TLDR
Recent findings suggest that another of its core components is represented by the c subunit of mitochondrial ATP synthase, the supramolecular entity that is believed to mediate MPT.
Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis
TLDR
Of 56 caspase-independent lethal compounds, modulatory profiling revealed ten inducing three types of regulated non-apoptotic cell death, and lead optimization of one of the ten resulted in the discovery of FIN56, a specific inducer of ferroptosis.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
TLDR
The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
Cell Death Signaling.
In multicellular organisms, cell death is a critical and active process that maintains tissue homeostasis and eliminates potentially harmful cells. There are three major types of morphologically…
Regulated necrosis: disease relevance and therapeutic opportunities
TLDR
This Review describes forms of regulated necrotic cell death, including necroptosis, the emerging cell death modality of ferroptosis (and the related oxytosis) and the less well comprehended parthanatos and cyclophilin D-mediated necrosis.
Cell death by mitotic catastrophe: a molecular definition
TLDR
It is proposed that mitotic catastrophe results from a combination of deficient cell-cycle checkpoints and cellular damage and failure to arrest the cell cycle before or at mitosis triggers an attempt of aberrant chromosome segregation, which culminates in the activation of the apoptotic default pathway and cellular demise.
Molecular mechanisms of regulated necrosis.
Mitochondria-Judges and Executioners of Cell Death Sentences.
Cell death by autophagy: facts and apparent artefacts
Autophagy (the process of self-digestion by a cell through the action of enzymes originating within the lysosome of the same cell) is a catabolic process that is generally used by the cell as a…
...
...