Molecular mechanisms of cancer metastasis: tumor and host properties and the role of oncogenes and suppressor genes.

@article{Nicolson1991MolecularMO,
  title={Molecular mechanisms of cancer metastasis: tumor and host properties and the role of oncogenes and suppressor genes.},
  author={Garth L. Nicolson},
  journal={Current opinion in oncology},
  year={1991},
  volume={3 1},
  pages={75-92}
}
The natural progression of benign tumors to malignancy and metastasis is characterized by their ability to circumvent microenvironmental controls on cellular proliferation, diversity, and positioning, and evolve into heterogeneous phenotypes, a process that probably involves qualitative and quantitative changes in gene expression. The oncogenes and suppressor genes that can effect tumor progression may control important points in the regulation of sets of genes that are ultimately responsible… CONTINUE READING

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