Molecular mechanisms of calcium-induced membrane fusion

@article{Papahadjopoulos1990MolecularMO,
  title={Molecular mechanisms of calcium-induced membrane fusion},
  author={D. Papahadjopoulos and S. Nir and N. D{\"u}zg{\"u}neş},
  journal={Journal of Bioenergetics and Biomembranes},
  year={1990},
  volume={22},
  pages={157-179}
}
We have reviewed studies on calcium-induced fusion of lipid bilayer membranes and the role of synexin and other calcium-binding proteins (annexins) in membrane fusion. We have also discussed the roles of other cations, lipid phase transitions, long chain fatty acids and other fusogenic molecules. Finally, we have presented a simple molecular model for the mechanism of lipid membrane fusion, consistent with the experimental evidence and incorporating various elements proposed previously. 
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A model for the molecular mechanism of the fusion of lipid bilayers is described and a novel, hypothetical lipid conformation, tentatively referred to here as extended, appears to be compatible with currently available experimental data. Expand
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