Molecular mechanisms of calcium-induced membrane fusion

  title={Molecular mechanisms of calcium-induced membrane fusion},
  author={Demetrios Papahadjopoulos and Shlomo Nir and Nejat D{\"u}zg{\"u}neş},
  journal={Journal of Bioenergetics and Biomembranes},
We have reviewed studies on calcium-induced fusion of lipid bilayer membranes and the role of synexin and other calcium-binding proteins (annexins) in membrane fusion. We have also discussed the roles of other cations, lipid phase transitions, long chain fatty acids and other fusogenic molecules. Finally, we have presented a simple molecular model for the mechanism of lipid membrane fusion, consistent with the experimental evidence and incorporating various elements proposed previously. 

Mechanisms of Initiation of Membrane Fusion: Role of Lipids

This review is focused on presenting one possible mechanism, involving so-called extended lipid conformation, and advocating the view, that in order to obtain a more complete understanding of this process it is necessary to merge the relevant physicochemical properties of lipids with the models describing the specific functions of proteins.

Membrane fusion in vesicles of oligomerizable lipids.

Greasing Membrane Fusion and Fission Machineries

This review focuses on the potential role of lipids in the generation of membrane curvature, and thus in the regulation of membrane fusion and fission.

Polymer Enhanced Fusion of Model Sperm Membranes as Induced by Calcium

Vesicle contents-mixing assays were used to study the fusion of a lipid membrane system that was designed to model the sperm plasma membrane, and the influence of PEG on ion-binding to membranes was examined.

Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity.

It is shown that the presence of synthetic peptides representing the transmembrane segments of the presynaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) synaptobrevin II or syntaxin 1A in liposomal membranes drives their fusion.

Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines

The convergence of these findings showing membrane integrity loss during biological membrane fusion suggests new mechanistic models for membrane fusion and the role of membrane fusion complexes.



Calcium-Induced Membrane Fusion: From Liposomes to Cellular Membranes

Although Ca2+ is involved in many biological membrane fusion phenomena, the mechanism of its action is not well understood and could participate directly in the fusion reaction by interacting with phospholipids or initiate a cascade of reactions which eventually mediate fusion.

Fusion of Phospholipid Vesicles Induced by Divalent Cations and Protons

Recent developments concerning the mechanism of membrane fusion induced by divalent cations and protons, and its modulation by the thermotropic properties of the phospholipid bilayer, monovalent cATIONS and polyamines in the medium, and free fatty acids in the membrane are discussed.

Early events in calcium-induced liposome fusion.

Role of Phospholipid Head Group Structure and Polarity in the Control of Membrane Fusion

Mammalian cell membranes fulfill a multiplicity of functions, some of which appear quite contrasting. For example, plasma membranes need to constitute a stable and reliable permeability barrier but

Annexins—New family of Ca2+-regulated-phospholipid binding protein

A model is proposed for the tertiary structure of a common calcium and phospholipid binding domain and two of these proteins (calpactins) also bind F-actin and are substrates for tyrosine kinases.