Molecular mechanisms of calcium-dependent excitotoxicity

@article{Sattler2000MolecularMO,
  title={Molecular mechanisms of calcium-dependent excitotoxicity},
  author={Rita Sattler and Michael Tymianski},
  journal={Journal of Molecular Medicine},
  year={2000},
  volume={78},
  pages={3-13}
}
Abstract. Excitotoxicity is thought to be a major mechanism contributing to neurodegeneration during central nervous system ischemia, trauma, and other neurological disorders. Briefly, synaptic overactivity leads to the excessive release of glutamate, the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate activates a number of postsynaptic cell membrane receptors, which upon activation open their associated ion channel pore to produce ion influx or efflux. This… Expand
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