Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells.

@article{Barradas2013MolecularMO,
  title={Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells.},
  author={Ana M. C. Barradas and V. Monticone and Marc Hulsman and Charl{\`e}ne B Danoux and Hugo Fernandes and Zeinab Tahmasebi Birgani and Florence Barr{\`e}re-de Groot and Huipin Yuan and Marcel J. T. Reinders and Pamela Habibovi{\'c} and Clemens A. van Blitterswijk and Jan de Boer},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2013},
  volume={5 7},
  pages={
          920-31
        }
}
Calcium phosphate (CaP) based ceramics are used as bone graft substitutes in the treatment of bone defects. The physico-chemical properties of these materials determine their bioactivity, meaning that molecular and cellular responses in the body will be tuned accordingly. In a previous study, we compared two porous CaP ceramics, hydroxyapatite (HA) and β-tricalcium phosphate (TCP), which, among other properties, differ in their degradation behaviour in vitro and in vivo, and we demonstrated… 
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Comparative proteomic analysis of human mesenchymal stromal cell behavior on calcium phosphate ceramics with different osteoinductive potential
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TLDR
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Bone morphogenetic protein Smads signaling in mesenchymal stem cells affected by osteoinductive calcium phosphate ceramics.
TLDR
Results implied that the CaP ceramics may initiate the osteoblastic differentiation of MSCs by influencing the expression of molecules in BMP/Smads pathway.
Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration
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Results suggest that CaSO4 scaffolds could have potential applications for bone regeneration and regulate BMP-2-induced MSC migration by differentially activating the PI3K/AKT pathway.
The Effects of Crystal Phase and Particle Morphology of Calcium Phosphates on Proliferation and Differentiation of Human Mesenchymal Stromal Cells.
TLDR
Within the limits of CaP precipitation, these data indicate the effect of both crystal phase and particle morphology of CaPs on the behavior of hMSCs.
Benefits of biphasic calcium phosphate hybrid scaffold-driven osteogenic differentiation of mesenchymal stem cells through upregulated leptin receptor expression
TLDR
The BCP hybrid scaffold for osteogenesis of MSCs is better than the coralline HA hybrid scaffolds by upregulating expression of leptin-R.
Submicron-scale surface architecture of tricalcium phosphate directs osteogenesis in vitro and in vivo.
TLDR
A novel submicron-structured TCP induces substantial bone formation and is resorbed at an equivalent rate, potentially through the control of osteoclast-like cells.
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