Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.

@article{Lu2020MolecularMO,
  title={Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.},
  author={Jiahui Lu and Rongjun He and Peilong Sun and Fuming Zhang and Robert J. Linhardt and An-qiang Zhang},
  journal={International journal of biological macromolecules},
  year={2020}
}
  • Jiahui Lu, R. He, +3 authors A. Zhang
  • Published 6 February 2020
  • Medicine, Chemistry
  • International journal of biological macromolecules
Ganoderma lucidum, commonly known as "Lingzhi" in Chinese, are well-known medicinal mushrooms. Lingzhi has been used in traditional Chinese herbal medicines for more than two thousand years. G. lucidum polysaccharides (GLPs) are present at high levels in G. lucidum cells and GLPs have molecular weights ranging from thousands to millions. GLPs have been widely studied for their various biological activities, such as antioxidant, antitumor, anti-inflammatory, antiviral, anti-diabetes, and… 
Isolation, structural properties, bioactivities of polysaccharides from Dendrobium officinale Kimura et. Migo: A review.
TLDR
The extraction, purification, structural characteristics, bioactivities, structure-activity relationships, and analyzes gaps in the current research on D. officinale polysaccharides are presented and it is hoped that this work may provide helpful references and promising directions for further study and development of the material.
Structure of water-soluble polysaccharides in spore of Ganoderma lucidum and their anti-inflammatory activity.
TLDR
Water-soluble polysaccharides (GLSP) obtained by hot water extraction possessed a strong anti-inflammatory activity through inhibiting the overproduction of NO and pro-inflammatory cytokines, like interleukin-6 and interleucin-1β induced by LPS, and implied the potential of GLSP on gut barrier protection.
The Versatile Functions of G. Lucidum Polysaccharides and G. Lucidum Triterpenes in Cancer Radiotherapy and Chemotherapy
TLDR
A review of complex molecules from G. lucidum that synergizes with radiotherapy and chemotherapy through multiple pathways, including oxidative stress, apoptosis, immune microenvironment, etc, in order to create more treatment options for cancer patients in the future.
Extraction, Structures, Bioactivities and Structure-Function Analysis of the Polysaccharides From Safflower (Carthamus tinctorius L.)
TLDR
This paper aims to systematically review the research progress in extraction, purification, structural characteristics, and bioactivities of SPS and PBPC, and provide basis for the in-depth study about their structure-bioactivity relationship.
Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum
TLDR
In this review, the activity of Ganoderma lucidum polysaccharides (GLP) is summarized, which has antioxidant, immunomodulatory, antineurodegenerative and antidiabetic activities.
Exploring the Protective and Reparative Mechanisms of G. lucidum Polysaccharides Against H2O2-Induced Oxidative Stress in Human Skin Fibroblasts
  • X. Shi, Wenjing Cheng, +6 authors Quan An
  • Medicine
    Clinical, cosmetic and investigational dermatology
  • 2021
TLDR
GLP could protect human skin fibroblasts from oxidative damage caused by H2O2 peroxide by enhancing enzyme activity and activating Keap1-Nrf2/ARE signaling pathway and will act as a natural antioxidant to protect the skin from oxidative stress damage.
Characteristics and antifatigue activity of graded polysaccharides from Ganoderma lucidum separated by cascade membrane technology.
TLDR
It is demonstrated that all graded GLPs could elongate swimming time, improve endurance and promote fatigue recovery, especially polysaccharides with molecular weights above 10 kDa, which might be potential agents with antifatigue activity.
Comparison of physicochemical and biochemical properties of natural and arginine‐modified melanin from medicinal mushroom Ganoderma lucidum
TLDR
Arginine‐modified melanin showed better solubility, higher color value, stronger antioxidant activity, and stronger inhibitory effect on pancreatic lipase activity in vitro than GLM, which opened possibilities for providing an excellent source of natural melanin in health food or food additives fields.
Advances in the extraction, purification, structural-property relationships and bioactive molecular mechanism of Flammulina velutipes polysaccharides: A review.
  • Yongxia Wang
  • Medicine, Chemistry
    International journal of biological macromolecules
  • 2020
TLDR
The current progress in the extraction, purification, structural characteristics and bioactivities of F. velutipes polysaccharides (FVPs) were reviewed and the structural-property relationships of FVPs were further discussed.
Advances in dietary polysaccharides as anticancer agents: Structure-activity relationship
Abstract Background The discovery of nutritious dietary supplements and side effect-free therapeutics are a priority in the current scenario of increasing cancer cases. Natural anticancer
...
1
2
3
4
...

References

SHOWING 1-10 OF 101 REFERENCES
Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities.
TLDR
This paper examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the possible mechanisms involved and suggests that the anti-tumor activities of GLPS are mediated by its immunomodulatory, anti-angiogenic, and cytotoxic effects.
Structure features of the intracellular polysaccharide from Ganoderma lucidum and the irrelative immune-anticancer activities of GLPs
TLDR
This study elucidated the irrelative immune-anticancer activities of GLPs; GLPs may not present anticancer activity only via immunomodulation and presented a broad-spectrum inhibition on most assayed carcinoma cells dose-dependently.
Ganoderma lucidum Polysaccharides as An Anti-cancer Agent.
TLDR
Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti -metastatic and anti-angiogenic effects.
From 2000years of Ganoderma lucidum to recent developments in nutraceuticals.
TLDR
A review of G. lucidum over the past 2000 years from prized ancient "herbal" remedy to its use in nutraceuticals and to the establishment of a 2.5 billion $ (US) industry is presented.
Carboxymethylation of a polysaccharide extracted from Ganoderma lucidum enhances its antioxidant activities in vitro
Abstract The chemical carboxylmethylated polysaccharide (C-GLP), which derived from water-insoluble crude Ganoderma lucidum polysaccharide (GLP), was prepared. Water solubility, chemical
Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.
TLDR
The histopathological observations of mice livers showed that GLPUD could significantly improve lipid metabolism disorder in hepatocytes, and might be tested as a more effective hypolipidemic drug.
Ganoderma: insights into anticancer effects
TLDR
In-vivo studies have confirmed the anticancer potential and the antimetastatic effects of compounds originating from Ganoderma and the combined use of G. lucidum with conventional chemotherapy/radiotherapy, but the methodology and the results are being questioned.
A novel water-soluble β-D-glucan isolated from the spores of Ganoderma lucidum.
TLDR
A neutral polysaccharide was isolated from sporoderm-broken spores of Ganoderma lucidum by hot-water extraction, graded ethanol precipitation, anion-exchange chromatography, and gel permeation chromatography and was elucidated to be a novel β-D-glucan featured by a 1,6-linked β- D-Glcp backbone with different length of branches.
Antioxidant and immunoregulatory activity of Ganoderma lucidum polysaccharide (GLP).
TLDR
GLP from fermented SCR could have potential applications in the medical and food industries and exhibited antioxidant activities in a concentration-dependent manner.
Effects of deproteinization methods on primary structure and antioxidant activity of Ganoderma lucidum polysaccharides.
TLDR
Purified GLP by enzymolysis maintained the strongest antioxidants activities with the retention rate of over 47.40%, and its deproteinization efficiency and polysaccharide loss ratio were 74.03% and 11.39% respectively.
...
1
2
3
4
5
...