Molecular mechanisms of benzodiazepine‐induced down‐regulation of GABAA receptor α1 subunit protein in rat cerebellar granule cells

@article{Brown1996MolecularMO,
  title={Molecular mechanisms of benzodiazepine‐induced down‐regulation of GABAA receptor α1 subunit protein in rat cerebellar granule cells},
  author={M. Brown and D. Bristow},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={118}
}
  • M. Brown, D. Bristow
  • Published 1996
  • Biology, Medicine
  • British Journal of Pharmacology
  • 1 Chronic benzodiazepine treatment of rat cerebellar granule cells induced a transient down‐regulation of the γ‐aminobutyric acidA (GABAA) receptor α1 subunit protein, that was dose‐dependent (1 nM‐1 μm) and prevented by the benzodiazepine antagonist flumazenil (1 μm). After 2 days of treatment with 1 μm flunitrazepam the α1 subunit protein was reduced by 41% compared to untreated cells, which returned to, and remained at, control cell levels from 4–12 days of treatment. Chronic flunitrazepam… CONTINUE READING
    54 Citations
    Flunitrazepam rapidly reduces GABAA receptor subunit protein expression via a protein kinase C‐dependent mechanism
    • 19

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