Molecular mechanisms of benzodiazepine‐induced down‐regulation of GABAA receptor α1 subunit protein in rat cerebellar granule cells

@article{Brown1996MolecularMO,
  title={Molecular mechanisms of benzodiazepine‐induced down‐regulation of GABAA receptor α1 subunit protein in rat cerebellar granule cells},
  author={M. Brown and D. Bristow},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={118}
}
  • M. Brown, D. Bristow
  • Published 1996
  • Biology, Medicine
  • British Journal of Pharmacology
    • 1 Chronic benzodiazepine treatment of rat cerebellar granule cells induced a transient down‐regulation of the γ‐aminobutyric acidA (GABAA) receptor α1 subunit protein, that was dose‐dependent (1 nM‐1 μm) and prevented by the benzodiazepine antagonist flumazenil (1 μm). After 2 days of treatment with 1 μm flunitrazepam the α1 subunit protein was reduced by 41% compared to untreated cells, which returned to, and remained at, control cell levels from 4–12 days of treatment. Chronic flunitrazepam… CONTINUE READING
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    54 Citations
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    Background Citations
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    Methods Citations
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    54 Citations
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    Chronic benzodiazepine treatment of cells expressing recombinant GABAA receptors uncouples allosteric binding: studies on possible mechanisms
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    γ‐Aminobutyric AcidA Receptor Function Is Desensitised in Rat Cultured Cerebellar Granule Cells Following Chronic Flunitrazepam Treatment
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    BENZODIAZEPINE-MEDIATED REGULATION OF a 1 , a 2 , b 1 – 3 AND g 2 GABAA RECEPTOR SUBUNIT PROTEINS IN THE RAT BRAIN HIPPOCAMPUS AND CORTEX
    • 4
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    Prolonged exposure to gamma-aminobutyric acid up-regulates stably expressed recombinant alpha 1 beta 2 gamma 2s GABAA receptors.
    • 17
    Effects of cocaine administration on receptor binding and subunits mRNA of GABAA‐benzodiazepine receptor complexes
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