Molecular mechanisms of autism: a possible role for Ca2+ signaling.

  title={Molecular mechanisms of autism: a possible role for Ca2+ signaling.},
  author={Jocelyn F Krey and Ricardo E Dolmetsch},
  journal={Current opinion in neurobiology},
  volume={17 1},
Autism spectrum disorders (ASDs) are a group of developmental disorders characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. The molecular mechanisms that underlie ASDs are not known, but several recent developments suggest that some forms of autism are caused by failures in activity-dependent regulation of neural development. Mutations of several voltage-gated and ligand-gated ion channels that regulate neuronal… CONTINUE READING
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