Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes.

@article{Yang2006MolecularMO,
  title={Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes.},
  author={Jeong-Yeh Yang and Mary Anne Della-Fera and Cass Nelson-Dooley and Clifton A. Baile},
  journal={Obesity},
  year={2006},
  volume={14 3},
  pages={
          388-97
        }
}
OBJECTIVE Determine the biochemical pathways involved in induction of apoptosis by ajoene, an organosulfur compound from garlic. RESEARCH METHODS AND PROCEDURES Mature 3T3-L1 adipocytes were incubated with ajoene at concentrations up to 200 microM. Viability and apoptosis were quantified using an MTS-based cell viability assay and an enzyme-linked immunosorbent assay for single-stranded DNA (ssDNA), respectively. Intracellular reactive oxygen species (ROS) production was measured based on… CONTINUE READING

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