Molecular mechanisms of antiproliferative effect of somatostatin: involvement of a tyrosine phosphatase.

@article{Lopez1996MolecularMO,
  title={Molecular mechanisms of antiproliferative effect of somatostatin: involvement of a tyrosine phosphatase.},
  author={Fr{\'e}d{\'e}ric Lopez and Jean P Esteve and Louis Buscail and Nathalie Delesque and Nathalie Saint-Laurent and Nicole Vaysse and C. L. Susini},
  journal={Metabolism: clinical and experimental},
  year={1996},
  volume={45 8 Suppl 1},
  pages={14-6}
}
A protein of 66 kd immunoreactive to anti-tyrosine phosphatase (PTP1C) antibodies coeluted with, and so may be associated with, somatostatin receptors (ssts) from rat pancreatic membranes. Also, anti-PTP1C antibodies immunoprecipitated functional ssts from pancreatic membranes, suggesting a PTP1C protein can associate with ssts at the membrane level. Somatostatin analog RC 160 had good affinity for sst2,3 and sst5 (IC50 = 0.2, 0.1, and 21 nmol/L) and low affinity for sst1 and sst4 (IC50 = 200… CONTINUE READING
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