Molecular mechanisms of androgen action.

  title={Molecular mechanisms of androgen action.},
  author={J K Lindzey and Mr B Vineeth Kumar and Mariann Grossman and Christian Young and Donald J. Tindall},
  journal={Vitamins and hormones},
Androgens directly regulate a vast number of physiological events. These direct androgen effects are mediated by a nuclear receptor that exhibits four major functions or activities: steroid binding, DNA binding, transactivation, and nuclear localization. The SBD consists of a hydrophobic pocket of amino acids that exhibits high-affinity, androgen-specific binding. Based on studies of mutant AR, it appears that a number of different amino acids contribute to the steroid binding characteristics… CONTINUE READING
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