Molecular mechanisms of androgen action--a historical perspective.

  title={Molecular mechanisms of androgen action--a historical perspective.},
  author={Albert O. Brinkmann},
  journal={Methods in molecular biology},
  • A. Brinkmann
  • Published 2011
  • Biology, Medicine
  • Methods in molecular biology
Androgens and the androgen receptor (AR) are indispensable for expression of the male phenotype. The two most important androgens are testosterone and 5α-dihydrotestosterone. The elucidation of the mechanism of androgen action has a long history starting in the 19th century with the classical experiments by Brown-Séquard. In the 1960s the steroid hormone receptor concept was established and the AR was identified as a protein entity with a high affinity and specificity for testosterone and 5… 

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Each form of dimerization utilized by the AR to achieve transcriptional competence is discussed and it is highlighted thatDimerization through multiple domains is necessary for optimal AR signaling.

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Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

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Steroid 5 alpha-reductase 2 deficiency.

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