Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.

@article{Raynor1994MolecularMO,
  title={Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.},
  author={Kendall Raynor and Hoi Kong and John Hines and Gary Kong and Jeffrey L. Benovic and Kazuto Yasuda and Graeme I. Bell and Terry David Reisine},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={270 3},
  pages={
          1381-6
        }
}
Prolonged exposure of opioid receptors to agonists can cause desensitization, a cellular event linked to tolerance. Although evidence exists for mu and delta opioid receptor desensitization, much less information is available concerning the in vitro regulation of kappa opioid receptors because no cell lines exist that specifically express this class of opioid receptor. Recently we have cloned the mouse kappa opioid receptor. After expression in COS-7 cells, this protein exhibits the… CONTINUE READING
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