Molecular mechanisms of adaptation to folate deficiency.

  title={Molecular mechanisms of adaptation to folate deficiency.},
  author={Ilan Ifergan and Yehuda G Assaraf},
  journal={Vitamins and hormones},
Folic acid is an essential vitamin for a wide spectrum of biochemical reactions; however, unlike bacteria and plants, mammals are devoid of folate biosynthesis and thus must obtain this cofactor from exogenous sources. Therefore, folate deficiency may impair the de novo biosynthesis of purines and thymidylate and thereby disrupt DNA and RNA metabolism, homocysteine remethylation, methionine biosynthesis, and subsequent formation of S-adenosylmethionine (the universal methyl donor) which in turn… CONTINUE READING
18 Citations
189 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 189 references

Similar Papers

Loading similar papers…