Molecular mechanisms of adaptation to folate deficiency.

@article{Ifergan2008MolecularMO,
  title={Molecular mechanisms of adaptation to folate deficiency.},
  author={Ilan Ifergan and Yehuda G Assaraf},
  journal={Vitamins and hormones},
  year={2008},
  volume={79},
  pages={99-143}
}
Folic acid is an essential vitamin for a wide spectrum of biochemical reactions; however, unlike bacteria and plants, mammals are devoid of folate biosynthesis and thus must obtain this cofactor from exogenous sources. Therefore, folate deficiency may impair the de novo biosynthesis of purines and thymidylate and thereby disrupt DNA and RNA metabolism, homocysteine remethylation, methionine biosynthesis, and subsequent formation of S-adenosylmethionine (the universal methyl donor) which in turn… CONTINUE READING
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