Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

  title={Molecular mechanisms of activity and derepression of alternative lengthening of telomeres},
  author={Hilda A Pickett and Roger R Reddel},
  journal={Nature Structural &Molecular Biology},
Alternative lengthening of telomeres (ALT) involves homology-directed telomere synthesis. This multistep process is facilitated by loss of the ATRX or DAXX chromatin-remodeling factors and by abnormalities of the telomere nucleoprotein architecture, including altered DNA sequence and decreased TRF2 saturation. Induction of telomere-specific DNA damage triggers homology-directed searches, and NuRD-ZNF827 protein-protein interactions provide a platform for the telomeric recruitment of homologous… CONTINUE READING
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