Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.

@article{Ching2011MolecularMO,
  title={Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.},
  author={Li-Chieh Ching and Yu Ru Kou and Song-Kun Shyue and Kuo-Hui Su and Jeng Wei and Li-Ching Cheng and Yuan-Bin Yu and Ching-Chian Pan and Tzong-Shyuan Lee},
  journal={Cardiovascular research},
  year={2011},
  volume={91 3},
  pages={492-501}
}
AIMS We investigated the molecular mechanism underlying the role of transient receptor potential vanilloid type 1 (TRPV1), a Ca(2+)-permeable non-selective cation channel, in the activation of endothelial nitric oxide (NO) synthase (eNOS) in endothelial cells (ECs) and mice. METHODS AND RESULTS In ECs, TRPV1 ligands (evodiamine or capsaicin) promoted NO production, eNOS phosphorylation, and the formation of a TRPV1-eNOS complex, which were all abrogated by the TRPV1 antagonist capsazepine… CONTINUE READING

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