Molecular mechanisms of action of ribavirin.

  title={Molecular mechanisms of action of ribavirin.},
  author={Jean L Patterson and R Fernandez-Larsson},
  journal={Reviews of infectious diseases},
  volume={12 6},
Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a broad-spectrum antiviral agent whose molecular mode of action remains remarkably controversial. This antiviral agent was approved by the U.S. Food and Drug Administration in 1986 for use as an aerosol for infants with serious infections due to respiratory syncytial virus. Ribavirin is and has been under clinical investigation for activity against a variety of viral illnesses, including those due to influenza virus, Lassa fever… CONTINUE READING