Molecular mechanisms of action of bisphosphonates.

@inproceedings{Rogers1999MolecularMO,
  title={Molecular mechanisms of action of bisphosphonates.},
  author={Michael J.C. Rogers and Julie C. Frith and Steven P. Luckman and Fraser P. Coxon and Helena L. Benford and Jukka M{\"o}nkk{\"o}nen and Seppo Auriola and Kattya M. Chilton and R Graham G Russell},
  year={1999}
}
BPs can be grouped into two general classes according to their chemical structure and the molecular mechanism by which they inhibit osteoclast-mediated bone resorption. The simple BPs can be metabolically incorporated into non-hydrolysable analogues of ATP that accumulate intracellularly in osteoclasts, causing osteoclast cell death by apoptosis. By contrast, the more potent N-BPs inhibit FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 71 CITATIONS, ESTIMATED 54% COVERAGE

[Mechanisms of action of anticatabolic drugs used in osteoporosis therapy].

  • Endokrynologia Polska
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2004
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2000
2018

CITATION STATISTICS

  • 6 Highly Influenced Citations

Similar Papers