Molecular mechanisms of RNAi: implications for development and disease.

@article{Rao2005MolecularMO,
  title={Molecular mechanisms of RNAi: implications for development and disease.},
  author={Meenakshi Rao and Shanthini Sockanathan},
  journal={Birth defects research. Part C, Embryo today : reviews},
  year={2005},
  volume={75 1},
  pages={
          28-42
        }
}
Research over the past few years has led to dramatic new discoveries on the role of double-stranded RNA (dsRNA) in the cell. RNA duplexes have been shown to orchestrate epigenetic changes, repress translation, and direct mRNA degradation in a sequence-specific manner. These diverse effects of dsRNA on gene expression have been termed RNA interference (RNAi). In addition to playing a role in viral defense and silencing transposons, RNAi also has a critical function in a number of developmental… CONTINUE READING

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